stock here: I haven’t been following Earthquakes that much, especially after my failed “Earthquake Alert” last month. But have been seeing unusual earthquake locations in Hawaii and now this……
stock here:
We need activism. These Bladerunners have taken it to an extreme level.
I hate the inflammatory nature of using terms like “Biden Crime Family”. They are white trash, pushed into power.
You heard of the FD-1023? Here it is as a PDF.
https://www.grassley.senate.gov/imo/media/doc/fd_1023_obtained_by_senator_grassley_-_biden.pdf
Grassley Obtains & Releases FBI Record Alleging VP Biden Foreign Bribery Scheme
Grassley, Comer to continue joint inquiry into FBI handling of significant, politically charged investigations
WASHINGTON – Sen. Chuck Grassley (R-Iowa) today released an unclassified FBI-generated record describing an alleged criminal scheme involving then-Vice President Joe Biden and a Ukrainian business executive. Grassley acquired the record, an FD-1023, via legally protected disclosures by Justice Department whistleblowers.
“For the better part of a year, I’ve been pushing the Justice Department and FBI to provide details on its handling of very significant allegations from a trusted FBI informant implicating then-Vice President Biden in a criminal bribery scheme. While the FBI sought to obfuscate and redact, the American people can now read this document for themselves, without the filter of politicians or bureaucrats, thanks to brave and heroic whistleblowers. What did the Justice Department and FBI do with the detailed information in the document? And why have they tried to conceal it from Congress and the American people for so long? The Justice Department and FBI have failed to come clean, but Chairman Comer and I intend to find out,” Grassley said.
“The FBI’s Biden Bribery Record tracks closely with the evidence uncovered by the Oversight Committee’s Biden family influence peddling investigation. In the FBI’s record, the Burisma executive claims that he didn’t pay the ‘big guy’ directly but that he used several bank accounts to conceal the money. That sounds an awful lot like how the Bidens conduct business: using multiple bank accounts to hide the source and total amount of the money,” House Committee on Oversight and Accountability Chairman James Comer said. “At our hearing with IRS whistleblowers, they testified that they had never seen or heard of this record during the Biden criminal investigation, despite having potentially corroborating evidence. Given the misconduct and politicization at the Department of Justice, the American people must be able to read this record for themselves. I thank Senator Grassley for providing much needed transparency to the American people. We must hold the Department of Justice accountable for seeking to bury this record to protect the Bidens.”
Grassley first disclosed the FBI’s possession of significant and voluminous evidence of potential criminality involving the Biden family last year. He has since worked to unearth the FBI record, eventually partnering with Comer on a subpoena to compel its public disclosure. After delays, the FBI provided a highly redacted version of the document to select members of the House of Representatives, but it remained shielded from the public and omitted key details, including references to recordings. Following the FBI’s failure to fully comply with the congressional subpoena, Grassley received the legally protected disclosure with limited redactions to protect a trusted FBI source, handling agents, department whistleblowers and identifiers related to other ongoing investigations.
‘Poluchili’
According to the FBI’s confidential human source, executives for Burisma, a Ukrainian gas company, brought Hunter Biden on the board to “protect us through his dad, from all kinds of problems.” At the time, Burisma was seeking to do business in the United States, but was facing a corruption investigation in Ukraine, led by then-Ukraine Prosecutor General Viktor Shokin. Regarding that investigation’s impact on its ambitions in North America, Burisma CEO Mykola Zlochevsky reportedly said, “Don’t worry Hunter will take care of all of those issues through his dad.” Zlochevsky reportedly stated that he had to pay $5 million to Hunter Biden and $5 million to Joe Biden, an arrangement he described as ‘poluchili,’ which is Russian crime slang for being “forced or coerced to pay,” according to the document.
“Back-up”
Zlochevsky claimed to have many text messages and recordings that show that he was coerced into paying the Bidens to ensure Shokin was fired. Specifically, he claimed to have two recordings with Joe Biden and 15 recordings with Hunter Biden. Zlochevsky also retained two documents, presumably financial records, as evidence of the arrangement, but said he didn’t send any funds directly to the “Big Guy,” a term understood to be a reference to Joe Biden. References to the “Big Guy” surfaced in communications involving other Biden family business arrangements independent of the Burisma arrangement. Zlochevsky claimed it would take investigators 10 years to uncover the illicit payments to the Bidens, according to the document.
Related:
10.17.2022 | FBI Possesses Significant, Impactful, Voluminous Evidence of Potential Criminality in Biden Family Business Arrangements
05.03.2023 | Grassley, Comer Demand FBI Record Alleging Criminal Scheme Involving Then-VP Biden
05.10.2023 | Comer and Grassley on FBI Failing to Comply with Subpoena Deadline
05.24.2023 | Comer & Grassley Blast FBI for Refusing to Provide Subpoenaed Record Alleging Then-VP Biden Engaged in a Bribery Scheme
05.31.2023 | Grassley & Comer to Wray: Provide the Unclassified Documents or Face Contempt
06.06.2023 | Grassley’s Message to the Biden DOJ and FBI: Quit Playing Games with the American People
06.12.2023 | Grassley: FBI Redacted References to Recordings in Biden Allegation Shared with Congress
06.21.2023 | Grassley, Graham Lead Senate Judiciary Committee GOP in Seeking Unredacted FBI Record at Center of Biden Allegations
07.18.2023 | Grassley, Johnson, Senate Republicans Demand DOJ and FBI Protect Whistleblowers Alleging Biden Bribery Scheme
The meaning of the number 201 to the Jesuits. The numerology behind the Coronavirus “Epidemic” and their relation to the main figures behind the corrupted Big Pharma companies.
The history goes that supposedly, in 1773, Pope Clement XIV suppressed the Jesuits worldwide, and they only survived because Catherine The Great protected exactly 201 Jesuits who continued to practice their religious ways. Their numerology can be seen everywhere when it comes to their order itself and the current crisis:
“The Jesuit Order” = 201 (Reverse Ordinal)
“Ignatius of Loyola” = 201 (English Ordinal)
“Jorge Mario Bergoglio” = 201 (English Ordinal)
“The Holy Bible” = 201 (Reverse Ordinal)
When it comes to the bible and revelation, the first case of coronavirus was confirmed in the United States on January 21, or 1/21, like 121, in Seattle, Washington, where the Bill and Melinda Gates Foundation is located, who co-hosted Event 201.
“Revelation” = 121 (English Ordinal)
“Coronavirus Outbreak” = 121 (Reverse Full Reduction)
“Bill and Melinda Gates Foundation” = 121 (Full Reduction)
“World Health Organization” = 121 (Reverse Full Reduction)
Everybody related to the crisis itself have Jesuit ties, some rather directly even:
The First International Mandatory Vaccination Policy Was Created by the Vatican.
The Bill & Melinda Gates Foundation is a Jesuit Missionary Congregation.
Bill Gates Reveals Family Goes to Catholic Church.
David Rockefeller on population control and depopulation.
The Rockefeller Foundation created the WHO & funds U.S. Public Health.
How Rockefeller wiped out natural cures to create the big pharma cartel.
Connection Between the Rockefeller Foundation, Johns Hopkins, and Gates Foundations.
Kary Mullis PCR inventor talking about Anthony Fauci.
The CDC’s swine Flu Fraud of 1976.
Pfizer to pay $2.3 billion, agrees to criminal plea. (Reuters 2009)
stock here: its always good to look back at research done “before everyone had a horse in the race”. I think I found one of the smoking guns to support Robert Kennedy’s Assertion greater deleterious effects on Whites and Blacks, and less effects on Jews and Finns.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360473/
So now Bobby Kennedy is saying these cleavage sites works different on different races.
The coding-region variants in ACE2 and TMPRSS2 from ~ 81,000 human genomes across 8 populations. a Coding-region variants in the genes encoding angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) across three human genome databases: (i) Genome Aggregation Database (gnomAD v3), (ii) Exome Sequencing Project (ESP), and (iii) 1000 Genomes Project (1KGP). SARS-CoV-2 utilizes the host cell factors angiotensin-converting enzyme 2 (ACE2) for entry into cells and the host transmembrane serine protease TMPRSS2 for SARS-CoV-2 spike (S) protein priming, offering potential pathway for therapeutic development in treatment of COVID-19. b Distribution of 61 deleterious variants in the ACE2 coding region identified in gnomAD (v3). Polyphen2 > 0.96 and CADD scores > 20 as cutoff identify putative deleterious variants. The upper panel using 3 colors shows the functional domains of ACE2, and the height of the vertical line represents the number of populations that carry this variant. The lower heatmap shows the allele frequencies (color key) of a variant across different populations. c Distributions of 63 putative deleterious variants in the TMPRSS2 coding region using the same approach of b. AFR, African/African-American; AMI, Amish; AMR, Latino/Admixed American; ASJ, Ashkenazi Jewish; EAS, East Asian; FIN, Finnish; EUR, Non-Finnish European; SAS, South Asian; PNA, population not assigned
ACE2 polymorphism analysis across different populations
Here, we investigated genetic susceptibility to COVID-19 by examining DNA polymorphisms in ACE2 (OMIM 300335) and TMPRSS2 (OMIM 602060) genes. We assembled a total of 437 non-synonymous single-nucleotide variants (SNVs) in the protein-coding regions of ACE2 and TMPRSS2 (Fig. 1a) from three databases: (i) Genome Aggregation Database (gnomAD v3: gnomad.broadinstitute.org, covering 9 geographical areas), (ii) Exome Sequencing Project (ESP: evs.gs.washington.edu/EVS/), and (iii) 1000 Genomes Project (1KGP, www.internationalgenome.org). We used ANNOVAR [9] to annotate all non-synonymous variants. By applying Polyphen2 and CADD (Combined Annotation Dependent Depletion) scores, we identified 63 potentially deleterious variants in ACE2 (61 in gnomAD) and 68 deleterious variants in TMPRSS2 (63 in gnomAD).
We found that the distribution of deleterious variants in ACE2 differs among 9 populations in gnomAD (v3). Specifically, 39% (24/61) and 54% (33/61) of deleterious variants in ACE2 occur in African/African-American (AFR) and Non-Finnish European (EUR) populations, respectively (Fig. 1b). Prevalence of deleterious variants among Latino/Admixed American (AMR), East Asian (EAS), Finnish (FIN), and South Asian (SAS) populations is 2–10%, while Amish (AMI) and Ashkenazi Jewish (ASJ) populations do not appear to carry such variants in ACE2 coding regions (Fig. 1b). Specifically, several variants, including p.Met383Thr, p.Pro389His, and p.Asp427Tyr, have been reported to slightly inhibit the interaction between ACE2 and the spike protein of SARS-CoV-1 [10], which caused the first global SARS-CoV-1 outbreak. Only AFR populations carry p.Met383Thr and p.Asp427Tyr variants, with allele frequencies of 0.003% and 0.01%, respectively (Fig. 1b). The p.Pro389His only occurs in the AMR populations, with an allele frequency of 0.015%. The p.Arg514Gly is a low allele frequency (0.003%) variant in AFR populations and is also somatically mutated in colon cancers and melanomas from The Cancer Genome Atlas (TCGA: https://portal.gdc.cancer.gov). This ACE2 variant is located in the angiotensinogen (AGT)-ACE2 interaction surface, which is anticipated to influence the renin-angiotensin system (RAS) function. The RAS is critical for regulation of blood pressure, sodium, and fluid balance, and its dysfunction is associated with cardiovascular and kidney disorders [11]. Residues Arg708/710/716 are located in the dimeric interface of ACE2 (Fig. 2a), and they are essential for its cleavage by TMPRSS2; this processing is required for augmentation of SARS-S-driven entry into host cells [12]. The EUR population carries the p.Arg708Trp, p.Arg710Cys, p. Arg710His, and p.Arg716Cys variants with allele frequency of 0.01~0.006% (Fig. 1a), while the EAS and the AMR populations only carry p.Arg708Trp and p.Arg710His with allele frequency of 0.04% and 0.01% respectively. In addition to these four variants, p.Leu731Phe has the highest allele frequency in the AFR and EUR populations. We further inspected the expression quantitative trait loci (eQTL) for ACE2 using the GTEx [13] and QTLbase [14] databases. We did not find any eQTLs for ACE2 from the GTEx, while we found one weak eQTL associated with ACE2 non-synonymous SNP (rs41303171) in the kidney from the QTLbase [14].
Structural view of the coding-region variants in ACE2 and TMPRSS2 and a proposed pharmacogenomics model of effective combination therapies for COVID-19. a Full-length structures of the sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19, red)–ACE2 (blue) heterodimer in its homodimeric form complexed with the receptor binding domain (RBD, mint) of SARS-CoV-2 (PDB ID: 6M17). Highly deleterious variants are labeled as yellow spheres on ACE2. Insets depict mutations in residues 383 through 427 (top) and residues 708 through 731 (bottom). b Homology model of the catalytic chain (256–492) of TMPRSS2. Highly deleterious mutations are labeled as yellow spheres. c A proposed model of effective combination therapies (i.e., hydroxychloroquine, E-64D (a protease inhibitor), and camostat mesylate (an approved TMPRSS2 for treatment of chronic pancreatitis in Japan)) for COVID-19 by blocking ACE2 and TMPRSS2 across different populations with three genotypes. Relationship among spike (S) protein of SARS-CoV-2, ACE2, and TMPRSS2 were shown as a triangle, with each pair connecting by physical binding (double-headed arrow) or cleavage (single-headed arrow). We propose three hypotheses for COVID-19 therapeutic options: (i) for patients with wild-type or naïve expression of ACE2 and TMPRSS2, hydroxychloroquine (or chloroquine, or E-64D) combined with camostat may offer more clinical benefit; (ii) for patients with polymorphisms or dysregulation on TMPRSS2, hydroxychloroquine or chloroquine monotherapy may offer more clinical benefit; and (iii) for patients with polymorphisms or dysregulation on ACE2, the patients who might have mild symptoms can recover in a short period. All three pharmacogenomics models for COVID-19 must be validated both experimentally and clinically before being used in patients
Altogether, these comparative genetic analyses suggest that ACE2 genomic variants may play important roles in susceptibilities to COVID-19 and its associated cardiovascular conditions by altering AGT-ACE2 pathway (i.e., p.Arg514Gly). In addition to differential polymorphisms which may explain susceptibility and even outcome in different ethnic populations, the fact that ACE2 is localized to Xp22.2 may help explain the observed male-associated risk. As such, even in the absence of variation in this gene, the monoallelic versus biallelic presence of this gene may impact the natural history and prognosis of COVID-19 in males.
TMPRSS2 polymorphism analysis across different populations
TMPRSS2 enzyme activity is important for coronavirus spread and pathogenesis in the infected host [15]. Our analysis indicates 4% (11/274) of non-synonymous variants of TMPRSS2 are stop-gained mutations and carried by AFR and EUR with low allele frequency (7.0 × 10−6~1.4 × 10−5). Meanwhile, 35% (22/63) and 59% (37/63) of deleterious variants in TMPRSS2 coding regions are carried by the AFR and EUR populations from gnomAD (v3), respectively (Fig. 1c). Each of the EAS, SAS, and FIN populations only carries 4 deleterious variants. We found 6 germline deleterious variants (p.Val160Met, p.Gly181Arg, p.Arg240Cys, p.Gly259Ser, p.Pro335Leu, and p.Gly432Ala) in the TMPRSS2 coding region, which are also identified as somatic mutations occurring in different cancer types from TCGA and COSMIC databases (https://cancer.sanger.ac.uk/cosmic).
We further evaluated the eQTL profile of TMPRSS2 using the GTEx [13] and QTLbase databases [14] as well. We found two eQTLs associated with TMPRSS2 non-synonymous SNPs (rs12329760 (encoding p.Val160Met), p = 4.54 × 10−5; rs75603675, p = 0.009) in the kidney and bone, respectively, using the QTLbase database [14], while there are no known eQTLs associated with TMPRSS2 non-synonymous SNPs from GTEx [13]. Notably, all populations carry p.Val160Met variants with the highest allele frequency (~ 25%), especially for the EAS population at a 40% allele frequency. Asp435 is a key residue for catalytic substrate binding of TMPRSS2 (Fig. 2b). We found that the p.Asp435Tyr, which has low allele frequency, is carried by the EUR population only (Fig. 1c). These unique but prevalent polymorphisms in TMPRSS2 offer potential explanations for differential genetic susceptibility to COVID-19 as well as for risk factors, including those with cancer and the high-risk group of male patients. Because TMPRSS2 is located on 21q22.3, we could speculate that individuals with Down syndrome would be at high risk for COVID-19 infection. In addition, oncogenic roles of TMPRSS2 may be linked to poor outcomes with COVID-19 as well [16], which should be studied in the future. Using single-cell RNA-sequencing analysis, Schuler et al. showed that TMPRSS2 expression was highest in ciliated cells and type I alveolar epithelial cells (AT1) and increased with aging in humans and mice [17]. This observation suggests that developmental regulation of TMPRSS2 may link the relative protection of infants and children from COVID-19. Thus, it should be of great interest to investigate the age-related polymorphisms for TMPRSS2, such as using the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort [18], in the future.
Host genetic factors guide personalized treatment of COVID-19
There are currently no approved effective medications against COVID-19. Several national and international research groups are working on the development of vaccines to prevent COVID-19, but effective vaccines not likely to be available for many months. Several potentially repurposable drugs (Fig. 2c), including melatonin [19], hydroxychloroquine, and chloroquine, are under investigation for treatment of COVID-19 [20]. A primary mechanism-of-action of hydroxychloroquine and chloroquine is to inhibit virus entry by targeting the endosomal pathway [20]. Hydroxychloroquine and chloroquine is known to increase the pH of endosomes, which inhibits membrane fusion, a required mechanism for viral entry into the cell [21]. Additionally, inhibition of SARS-CoV-2 could be due to differential glycosylation of both ACE2 and the spike protein [21]. As shown in Fig. 1b, several variants identified in the AFR and AMR populations, including p.Met383Thr, p.Pro389His, and p.Asp427Tyr (the pathogenic variants in ACE2 slightly inhibit interaction with the S protein), may influence the clinical efficacy of hydroxychloroquine or chloroquine. This may help explain why treatment of hydroxychloroquine was not significantly associated with difference in in-hospital mortality [22]. However, further pharmacogenomic studies that integrate drug response and genetic data from patients with COVID-19 are urgently needed.
In addition to the endosomal pathway, fusion of viral and host cellular membranes through S protein conformational changes is another way for coronavirus entry into the host cell [23]. This process can be blocked by a TMPRSS2 inhibitor (camostat mesylate, a drug approved in Japan) [5]. The mechanisms whereby TMPRSS2 promotes cellular entry of SARS-CoV-2 can be summarized by two aspects based on its proteolytic function (Fig. 2). The first is S protein cleavage at S1/S2 and S2’ sites, which might be the reason why SARS-CoV-2 entry into cells depends on TMPRSS2. The infection and pathogenesis of SARS-CoV-2 depends on the presence of TMPRSS2, in the face of the cellular elevated pH environment [5, 24, 25]. The inhibitors of endosomal acidification such as CatB/L inhibitor E-64D and hydroxychloroquine/chloroquine may only work for TMPRSS2-absence patients who are infected by SARS-CoV-2, and may have less effect or no effect for the patients with wild-type of TMPRSS2 [5, 24]. Therefore, the EUR and AFR populations might be more sensitive to hydroxychloroquine or chloroquine by carrying missense variants and stop-gained variants on TMPRSS2 (Figs. 1c and and2c).2c). Yet, for patients who have wild-type of ACE2 and TMPRSS2, a combination of camostat with hydroxychloroquine or chloroquine may have better clinical benefit. However, all discussed treatment strategies must be validated by randomized controlled trials before clinical use. The second mechanism is cleavage of ACE2 by TMPRSS2 at Arginine 697 to 716 [12], which enhances viral uptake. Thus, the EUR population with p.Arg708Trp, p.Arg710Cys, p.Arg710His, and p.Arg716Cys variants in ACE2 may have mild symptoms after SARS-CoV-2 infection as ACE2 loses the cleavage site by TMPRSS2 and changes the ACE2 dimer formation [26] (Fig. 2c).
Discussion and future directions: call for host genetics initiative for COVID-19
A few limitations merit consideration. Current analysis examined massive genomic data from general population, not COVID-19 patient-specific populations. All genetic associations identified in current study are urgently needed to be tested in COVID-19 patients in the near future. As the high-resolution protein structure of TMPRSS2 is not yet available, further functional observations and clinical validation are warranted for all abovementioned genetic and pharmacogenomics findings. We anticipate that large-scale genome-wide association studies (GWAS) are urgently needed to identify likely causal host genetic risk factors for severe COVID-19 outcomes using genetic data from patients with COVID-19; such knowledge will improve risk stratification of individuals exposed to or testing positive for SARS-CoV-2 and allow for precision medicine interventions for COVID-19. A COVID-19 host genetics initiative is already underway to bring together the human genetics research community to generate, share, and analyze data in a search for the genetic determinants of COVID-19 susceptibility, severity, and outcomes [27]. The first COVID-19 GWAS identified the 3p21.31 gene cluster (including SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1) as a genetic susceptibility locus in severe patients with COVID-19 and respiratory failure [28]. Yet, our study aims to look for SNPs associated with disease severity of COVID-19, but not disease susceptibility. In summary, systematic identification of the genetic determinants of COVID-19 susceptibility, severity, and clinical outcome, including both virus and host factors (e.g., ACE2 and TMPRSS2 polymorphisms), could guide personalized treatment in the emerging COVID-19 pandemic and even explain current epidemiologic observations (i.e., males, elderly at high risk, and clinical comorbidities) and natural history.
Conclusions
This comprehensive comparative genetic analysis of approximately 81,000 human genomes suggested possible associations of ACE2 and TMPRSS2 DNA polymorphisms with COVID-19 susceptibility, severity, and clinical outcomes. We found that ACE2 polymorphisms were more likely to be associated with cardiovascular and pulmonary conditions by altering the angiotensinogen-ACE2 interactions, such as p.Arg514Gly in the African/African-American population. Unique but prevalent polymorphisms in TMPRSS2, including p.Val160Met (rs12329760), may provide potential explanations for differential genetic susceptibility to COVID-19 as well as for risk factors, including cancer and the high-risk group of male patients. We highlighted that polymorphisms in ACE2 or TMPRSS2 could guide personalized treatments (i.e., hydroxychloroquine and camostat) for COVID-19. In summary, this study suggested that ACE2 or TMPRSS2 DNA polymorphisms were likely associated with genetic susceptibility to COVID-19, which calls for a human genetics initiative for fighting the COVID-19 pandemic.
Acknowledgements
We thank all helpful discussions and critical comments regarding this manuscript from the COVID-19 Research Intervention Advisory Committee members at the Cleveland Clinic. SCE is the Alfred Lerner Memorial Chair of Innovative Research and CE is the Sondra J. and Stephen R. Hardis Endowed Chair of Cancer Genomic Medicine at the Cleveland Clinic.
Abbreviations
| 1KGP | 1000 Genomes Project |
| ACE2 | Angiotensin-converting enzyme 2 |
| CoV | Coronavirus |
| COVID-19 | Coronavirus Disease 2019 |
| eQTL | Expression quantitative trait loci |
| gnomAD | Genome Aggregation Database |
| MERS | Middle East respiratory syndrome |
| SARS | Severe acute respiratory syndrome |
| SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 |
| ESP | Exome Sequencing Project |
| S | Spike |
| TMPRSS2 | Transmembrane serine protease 2 |
Authors’ contributions
F.C. conceived the study. Y.H., J.Z., and W.M. performed all experiments and data analysis. A.K., M.K.C, N.S., L.J., C.E., and S.E. discussed and interpreted all results. F.C., Y.H., C.E., and S.E. wrote and critically revised the manuscript with contributions from other co-authors. All authors read and approved the final manuscript.
Funding
This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) under Award Number R00HL138272 and the National Institute of Aging under Award Number R01AG066707 to F.C. This work was supported, in part, by the VeloSano Pilot Program (Cleveland Clinic Taussig Cancer Institute).
Availability of data and materials
All population genetic data used in this study are free and available at three databases: (i) Genome Aggregation Database (gnomAD v3: gnomad.broadinstitute.org, covering 9 geographical areas), (ii) Exome Sequencing Project (ESP: evs.gs.washington.edu/EVS/), and (iii) 1000 Genomes Project (1KGP, www.internationalgenome.org).
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
The content of this publication does not necessarily reflect the views of the Cleveland Clinic. The authors declare no competing interests.
Footnotes
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Articles from BMC Medicine are provided here courtesy of BioMed Central
———————————————————————————
So now Bobby Kennedy is saying these cleavage sites works different on different races.
In mid 2021, as I discovered the horrific experiment that was going on….they took the logistically insane method of sending their bad batches to very spread out states. The theory was that they were collecting data on how the specific batches affected people in different demographics, races, age, and even temperature. Shortly after publishing the undeniable data….Google banned my website on blogger, and then started erasing my history for 10 years. over the target! I had made a full backup a week or two back, I knew I was getting close to the real story and was therefore at risk.
I don’t have a firm opinion on whether “the furin cleavage site” makes effects of different races from COVID and also the Spike S protein of the Injections, in all their formulations.
I’ll add more when I get more. Research has been tough. But maybe this blood type meme will play out well.
According to the American Red Cross, the following statistics show the most common blood types in the U.S. based on the donor population:
- African American: 47% O-positive, 24% A-positive, and 18% B-positive
- Latin American: 53% O-positive, 29% A-positive, and 9% B-positive
- Asian: 39% O-positive, 27% A-positive, and 25% B-positive
- Caucasian: 37% O-positive, 33% A-positive, and 9% B-positive
Most rare blood types by ethnicity
The least common blood type in the U.S. is AB-negative, with less than 1% of the population having this type.
Statistics from the American Red Cross show that the following are the most rare forms of the major eight blood types in the U.S. based on the donor population:
- African American: 0.3% AB-negative, 1% B-negative, and 2% A-negative
- Latin American: 0.2% AB-negative, 1% B-negative, and 2% both A-negative and AB-positive
- Asian: 0.1% AB-negative, 0.4% B-negative, and 0.5% A-negative
- Caucasian: 1% AB-negative, 2% B-negative, and 3% AB-positive
—————————————————— I asked AI to help, and it appears that AI is becoming more woke….”The concept of race is a social construct” hmmmm
here it is
As of my last update in September 2021, there is no comprehensive chart that provides percentage breakdowns of blood types for different races, including the Ashkenazi Jewish population. Blood type distribution can vary widely based on geographical location, cultural background, and historical migrations. Additionally, the concept of “race” is complex and not based solely on genetic factors, so trying to associate specific blood type distributions with races can be misleading.
However, I can provide you with some general information about blood type distributions in different populations. Keep in mind that these numbers are approximate and may not be fully up-to-date:
- ABO Blood Group System:
- Blood Type O: This is usually the most common blood type worldwide.
- Blood Type A: Common in populations of European, African, and Asian descent.
- Blood Type B: Common in populations of Asian and African descent.
- Blood Type AB: Relatively rare, and often more prevalent in mixed populations.
- Rh Factor:
- Rh-positive: This is the most common Rh factor in most populations.
- Rh-negative: Relatively less common compared to Rh-positive, and its distribution can vary across different ethnic groups.
As for the Ashkenazi Jewish population, they are an ethnoreligious group with Ashkenazi Jews primarily having European ancestry. It’s important to note that their blood type distribution would likely resemble the blood type distribution of European populations.
For any specific and up-to-date data on blood type distributions in different populations, it’s best to refer to recent studies and medical databases. The distribution of blood types can also change over time due to various factors such as migration, intermixing of populations, and medical advances.
Remember, blood type information is essential for medical purposes, such as blood transfusions, but it should not be used to draw conclusions about a person’s race or ethnicity. The concept of race is a social construct and not a valid biological categorization. Genetic variation within and between populations is much more complex and nuanced than can be captured by broad racial categories.
Biden’s dog Commander sent Secret Service officer to hospital, bit 6 others after replacing first pooch Major
2 bad “Dogs” in a row….I think it is the owners…..
https://nypost.com/2023/07/25/biden-dog-commander-bit-or-threatened-10-people-sent-one-to-hospital/
WASHINGTON — President Biden’s nearly 2-year-old German shepherd Commander bit seven people in a four-month period after former first dog Major was ousted from the White House over similar aggressive behavior, according to internal Secret Service communications reviewed by The Post.
The shocking spate of incidents involving Commander — none of them previously reported — mirrors attacks involving Major, who the White House says was given to family friends after biting many Secret Service members in 2021.
In the most serious documented incident involving Commander, the White House physician’s office on Nov. 3, 2022, referred a bitten Secret Service uniformed officer to a local hospital for treatment after the dog clamped down on their arm and thigh, according to emails released under the Freedom of Information Act to conservative legal group Judicial Watch.
Records show Commander broke the skin of a different Secret Service member’s hand and arm weeks later after the president unleashed him outside the White House following a family movie night — and the following month, Commander bit the back of a security technician at Biden’s Wilmington, Del., home.
Categories
Creepy Guy Controlling Senator
stock here: this is creepy. I wonder if it is AI?
This guy in the background seems to be actually speaking through the other guy, and yes I'm serious!… pic.twitter.com/Bu7QPD9qVl
— CtrlAltDelete (@TakingoutTrash7) July 25, 2023
stock here. AI ChatGDP does a good job of writing first drafts of whatever you want, even basic research.
I tried Youbuild.AI and was hoping to get an executable file that did it all. Not quite, not close….but it did come up with a rational plan to obtain the data
an app that downloads that last weeks earthquake data from the USGS website and transfers the data into CVS format and make a separate worksheet with all the deep earthquakes over 300km, and all the large earthquake over 5.7 magnitude
Here is what I asked it, and below is what it generated.
——————————————————
First, log into the USGS website and select the link entitled ‘Earthquake Data.’
Next, select the option to ‘Display Data’ and then click ‘Submit.’
Then select ‘Export Data’ dropdown menu and choose ‘CSV’ as the format.
Next, select ‘Last Week’ as the ‘Time’ option and click ‘Submit’.
Once the data is displayed, click ‘Download File.’
Once the data has been downloaded, open the CSV file.
Using a spreadsheet program such as Microsoft Excel or Google Sheets, create a separate worksheet.
new worksheet, use the data downloaded from the USGS website to create a table with the following columns: Magnitude, Depth, Region, and Time.
Next, use the filter function to filter out all earthquakes with a magnitude less than 5.7 and a depth greater than 300km.
Finally, save the worksheet as an Excel (.xlsx) or CSV file.
Your table is now ready to be used!
—————————————————- They give you a list of other apps that people have built. Looks like AI hates Trump.
This is old news, now they are warning of drug shortages…..
stock here: This is as expected. Note that these are “clearances” aka Approval of Personal Pensions to the disabled. These are the ones that lived, there are many more that died.
I made this chart from all the data.
Check my source documents if you have the wherewithal to data crunch.
https://phinancetechnologies.com/HumanityProjects/PIP%20Analysis-Causes.htm
Are we seeing “Turbo Cancers”? Prior average 2800, new average 4000. Disabling Cancers, so I would say Turbo.
Psychiatric — went from 9000 to 24000. Keep in mind these are not just people seeking treatment, these are people newly disabled.
Neurological: Note how additional Vaccine Boosters all but stopped at beginning of 2022, but the disabilities continued “strong” and even accelerating.
This is the only category that just went up and did not skyrocket
Categories
YouBuild.AI
I
stock here, this thing will write code for you. I haven’t tried it yet, but wanted to document it so I don’t lose it. I am putting together a set of free and almost free AI Resources.
Categories
The Satanic Trans Agenda
Sent in by the FC, at the end is the full infamous clip of Joan Rivers Stating we all know….Obama is gay and Michelle is a transgender.
stock here: Some reading material. He gets much of it correct. But here’s the thing, he wants Trump back in office.
The left uses Trump to create division and hatred, and uses the useful idiot liberals who then suck down all the leftist non-sense, or at least don’t campaign against it.
And here is this….Trump thinks that Zelensky is a “brave man” and that is pretty much all I need to know about the New Trump…..he still doesn’t understand the most important things. The war in Ukraine is for sure funding the commie leftist causes within the USA.
I know I will piss off alot of people by saying that Trump is not a good choice to run for President, he should step back and support the next well like candidate….someone who can swing some Libs too. I imagine JFK jr. would run as an independent but I think he know that would never work anyway.
Dan Bongino, who is an “adoring” Trump fan, is pandering the story that Trump will make better personnel decisions this time….and I don’t buy it. Christopher Wray, anyone? He is still there at the head of the Jan 6 abusing FBI.
Bottom line is — We do not need Trump, we simply need elections that are not corrupted.
https://roninhardjan.substack.com/p/section-nine
———————————– Check out the guy’s substack too
I believed The Deep State was losing its power, but wanted a Republican back in the White House in 2024 to keep up the charade of democracy. I may have been wrong.
They probably want DJT to get the GOP nomination because they feel confident he’ll lose to the “Democratic” nominee. I’m afraid they still wield the majority of power in the USSA.
Ronin’s Revelations is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.
When The (Bureaucratic) Deep State squeals about Donald Trump it may be real fear. That’s good for you and me!! I have my work cut out for me updating “America’s Shadow Government” as a result of this…
After brushing up on Trump’s actions I’ve seen enough evidence to vote for him for a third time. In 2016 Americans’ consensus was that we might need a bull in the China shop. He even got a few far-Left votes from the Hitlery haters but lost those in 2020). DJT OVER-DELIVERED.
Hopefully DJT reads “America’s Shadow Government” as he faces an uphill climb to convince American voters he’s for real. Civil liberties proponents better hope it doesn’t prove to be a Sisyphean climb.
The Deep State sure as hell isn’t our ally. Never has been never will be. I would be surprised if many DC bureaucrats wanted a weak military as the ChiComs, AND their sympathizers might.
How could they possibly with American and European defense contractors lining their pockets with blood money? I am referring to DC’s unelected bureaucrats (rats), not ordinary citizens who would prefer more spending on social services.
I would also imagine there are European concerns who would rather have the seat of power in Europe rather than in the US (or at least it’s a possibility). They may not care.
There must be infighting among global “ruling” elites much as there’s confusion among journalists attempting to suss out their relationships. In some instances that interconnectedness may protect us, but does not include the WHO’s “Pandemic” Treaty.*
One would hope these differences among “ruling” elites would be enough to keep us safe, but 9/11 and CoVid suggest otherwise. There doesn’t appear to be so much as a half-assed investigation into the CoVid-19 outbreak. All the public’s left with is the coincidental Event 201 pandemic exercise.
*[The Event 201 exercise conducted by Johns Hopkins, the World Economic Forum (private arm of the UN and WHO [in other words Amerika & the Chinese Communists]), and the Bill & Melinda Gates foundation four months PRIOR TO the CoVid-19 outbreak demonstrated an alarming willingness to collaborate in order to reach elitists’ shared agenda.
If there was a natural outbreak of avian flu a few years following Event 201, and our authorities were better equipped to handle it, it would be another matter entirely, but that isn’t what happened. I don’t believe Fauci, Gates, and Schwab were framed. That’s wishful thinking more suitable for fairytales.
Any bets on how long it takes Melinda to remove her name from the foundation (hard to root against a Dallas gal)? I’d be anxious to disassociate from Bill Gates ASAFP. We shouldn’t assume everyone is evil, but I have some serious questions about her ex-husband (tech titan turned vaccine “expert” for Americans who trust government [CIA] media). Lord help us, surely young people are no longer using Facebook (or other social media) as their primary news aggregator. FB is crawling with spooks.]
It’s one cover up after another, and Lord knows what else we are NOT privy to. At least there’s enough dirt on 9/11 and JFK to keep our government under pressure. It’s why they have to censor, distort (spin) and outright lie constantly.
A few parts of this article seem a little redundant to me, but it may help to have sound bites to compliment “America’s Shadow Government”, and for sharing as well. I never intended for my manuscript to become a four hour read. Yikes.
I’ll also do a series of essays beginning with “SECTION NINE” that should clear up some confusion, then I’ll try to hew to chronological order on most subsequent articles when possible while attempting to steer clear of CoVid-19 AND 9/11 in the majority. However, referencing Event 201 was necessary to shed some light on my manuscript (to better clarify its moniker The Deep State). It’s tricky…
The Biden administration is 100% full speed Deep State (without Trump to gum up the works). The Deep State = Amerika = The United Socialist States of Amerika (red shadow government). The Deep State has modeled us after the CCP police state without many Americans realizing it (the CIA has always served The Deep State and is who most Americans receive their news “programming” from).
This is the simplest way to view our government without overcomplicating things.
If these “hostile to democracy” interests are able to cooperate with one another to reach common goals, surely Liberal and Conservative voters can figure out a way to get along and save our country. Most people seem worn out and less likely to argue, so now is as good a time as ever.
I’ll continue to update “America’s Shadow Government”.
It might not be a bad idea to review it occasionally if you learned something from it (I’ve added a ton over the last several weeks). At some point I’ll put it down, but not until it’s as accurate as possible. I’ll need to clear up any doubt regarding DJT and also to simplify my writing on The Deep State if necessary. The majority of information should still be spot on and worthwhile to read.
I will look for updates like today’s readers may miss, and share them as well.
Today’s was important as I have felt the confusion many voters have felt (Trump supporters and non-supporters alike). I’d love to hear Trump continually spell out, in as presidential a manner as possible, why he’s the right man to lead America out of darkness. Let’s go DJT!!!!
The point of my writing is to reach a significant minority of Liberals in order to reform our government nonviolently, not to create another rightwing feedback loop (those are a dime a dozen, but are also a critical part of our support networks). If you enjoy these essays, please share them with your Liberal friends and family.
Long term we miraculously need to get Trump re-elected. I don’t believe that’s possible without a significant minority of Liberals and Independents voting for him. We have a little over a year to reach what remains of the Left who also cherish our civil liberties. There’s bound to be a few.
Young Liberals will turn out in droves to vanquish Trump a second time and also to vote for student loan forgiveness. We must get out in front of the young AND dumb (lacking life experience) onslaught. Most of us were young and dumb once so this isn’t a personal attack.
Is there any reason Conservatives can’t offer student loan forgiveness (other than the fact most are Neo-Cons and RINOs who support Biden’s Deep State agenda)? The GOP must adopt a do whatever it takes to win mentality if Republicans are in fact for real. I haven’t seen anything in recent years to suggest that they are. All I see is them rolling over again and again. Shaking their fists but not taking action like bad Kabuki theater.
With Biden in office there is NO ONE to slow down The Deep State (who many suspect facilitated the John F. Kennedy assassination as well as the 9/11 attacks through its use of the CIA).
[“Heed Truman’s Call to Rein in the CIA” – Peter Fenn (link pending):
Peter Fenn’s article was written two years before Trump took office.
As you can see, The Deep State has turned a monster (the CIA) loose on the American people.]
If Trump is re-elected he must show more Deep State bureaucrats like James Comey (Blinken and Nuland) no mercy, and fire them as quickly as possible. Unelected appointees were very harmful to Donald Trump’s presidency as well as to we the people’s individual freedoms. They must be fired for the American experiment to survive and thrive. That’s something every American should want.
I will post another article in a few days regarding Trump’s non-renewal of The “Patriot” Act’s Section 215. It would be much better if he had said “for the people” rather than “for Russiagate” (himself). Maybe he did? I’ve also heard the “Biden” administration (Deep State) is pressuring the courts to rule in favor of free speech “controls” or “limitations”. I’ll do some research before I publish.
Additional mission objectives covered in “America’s Shadow Government” include Doctors, Hollywood, Law Enforcement, Military, NBA, and Writers standing up to what’s fast becoming the Amerikan (USSA) establishment. There is great strength in numbers.
I never planned on writing, but let’s hope these revelations and some elbow grease and duct tape can turn this ship around…
stock here: I created this image of a German Shepherd doing TIG Welding, note the cool gloved snout, very creative. But it needs a label. They are going to state that all the images of Hunter doing illegal and immoral stuff were AI generated….I see that coming for sure.
Are those colored squares at the bottom a form of labeling?
My 10 cent AI created this image
I am on a Facebook group that follows Leonardo.AI, the command prompts mean everything in terms of getting what you want and an effective image.
stock here: One of the End Goals is Tyranny. In UK they are
prosecuting 100s of people a month, and 28,000 total for breaking the lockdowns.
If the person objects to the fines (6000 to 10,000 GBP) then the Government will without notice before or after, “try their case in absensia” (without the defendant being present, sometimes not even being aware they are being tried, as in the letter never arrived).
Old people receiving government benefits see the Tyrants that be, simply take away their benefits until the fine is paid.
stock — Well maybe he did more than just that….oh looks like he opened a line of credit, although there are no claims of wrong doing — it looks like a BS nothing burger to me
A US$55 million loan became the primary focus of federal prosecutors, which initially was discovered as a footnote in an April 2020 financial report. The team had taken out the credit line 16 months earlier without the knowledge and required approval of Snyder’s minority partners, Robert Rothman, Dwight Schar, and Frederick W. Smith, who owned 40% of the team collectively.[76]Bank of America officials repeatedly asked team executives for proof that the board had approved the loan, but team executives ignored all requests before the loan closed.[76] According to arbitration documents, the partners demanded that the NFL investigate the origin of Snyder’s loan, yet neither NFL commissioner Roger Goodell nor the NFL arbitrator investigated the allegations. Four days after the partners asked the NFL to seek proof that the loan was legally obtained, the NFL shut down arbitration proceedings.[76]
Dan Snyder is Jewish….maybe he didn’t cowtow to all the rules of the Tribe?
This is the original story. A rabbit hole run for sure. Why they targeted this guy is a story all by itself. I don’t have that answer
stock here: this is part of the 4th Turning, this is where we are at. Please take a good look Mary Jo White. Besides lambasting to mostly innocent, protecting the guilty, and aiding the Opioid Epidemic (those are her good points) she is just overall a horrible person.s
https://en.wikipedia.org/wiki/Mary_Jo_White
Return to private practice
Following her departure as Chair of the SEC, White rejoined Debevoise & Plimpton in February 2017.[26] In that same year, White was a member of a National Football League‘s external expert advisory panel on domestic violence, reviewing allegations against Ezekiel Elliott. He was suspended for six games.[27]
In 2017, White was retained by the University of Rochester to investigate professor T. Florian Jaeger, by whom sixteen students had complained of being sexually harassed. White’s firm was hired to conduct an independent investigation but proceeded without any input from the plaintiffs from the case, due to their pending litigation.[28] White’s team broke confidentiality agreements with witnesses by making public names that they had promised would remain confidential.[29] Based on White’s legal opinion that no laws had been broken,[30] the University of Rochester argued that the case should be dismissed. The judge, however, sided with the plaintiffs in a 58-page ruling which “repeatedly knocked down specific rebuttals from the university” including White’s claims.[31] The case later settled with the plaintiffs with no-fault admitted for $9.4 million.[32]
In August 2018, White chaired the investigation related to Ohio State‘s football coach Urban Meyer‘s denials of knowing about domestic violence committed by one of his former assistant coaches, Zach Smith.[33]
In August 2019, White was retained by Les Wexner as a criminal defense attorney in matters to the investigation of Jeffrey Epstein.[34]
Throughout her career, White has represented members of the Sackler family and Purdue Pharma in litigation brought by victims of the opioid epidemic.[35] In 2006, White, along with Rudy Giuliani, pressured the Department of Justice not to pursue criminal charges against key executives in Purdue Pharma.[36] Mary Jo White’s advocacy meant that Purdue was able to aggressively continue to sell OxyContin across the United States.[36] White continued to represent Purdue Pharma after this, advocating for a settlement in bankruptcy court that would have absolved the Sackler Family of any criminal liability from their role in the opioid epidemic.[37] That settlement was overturned by the Southern District of New York in December 2021.[38]
Categories
Quake Update
My Call for a VLQ Very Large Quake expires today, Friday. After the dearth of quakes on Tuesday, the daily quantity went to the slightly high side around 30 on the USGS report. This of note though….never saw 3 quakes in the same area(but not the same spot) at exactly the same depth 156 km, and a 4th one at 161km).
Not my favorite podcast overall,, but occasionally good stuff. This one is highly recommended. They fall short of recognizing the Satanic and Psychopathic trends behind much of what ails us. We need more than a “resolution” we need a win.
Let me know what you think.
This is on Spotify.
stock here: well its fast, really fast. Somewhat trite, and I could improve these with a little work. AI is a useful tool to create your first draft. I used it to create a Cease and Desist letter, it looks pretty good.
AI loves some words like intertwined, might, light, bright
—————————————————
In the heart of a garden, where life blooms bright, A sanctuary stands against the world’s dark plight,
With organic might, it shields and defends, From the World Economic Forum, their twisted trends.
Young Global Leaders, wrapped in a facade, Macron, Trudeau, steering a misguided charade,
But amidst the green foliage, their influence wanes, For truth and resilience the garden sustains.
Amidst the chaos where farmers and truckers face, The garden offers solace, a haven and embrace,
An abundant haven, where food and hope combine, Against the attacks on those who toil the land, they malign.
The world cries, “Fight carbon!” with misguided might, Yet the garden knows better, it reveals the light,
For carbon, the essence of life’s very core, Is the key to growth, the earth’s blessings to store.
So tend the garden with love, let its roots run deep, Protecting us from falsehoods, we shall keep,
In nature’s embrace, we’ll find our way, Amidst the chaos, hope’s seeds we’ll sow and lay.
Via research from the Flying Cuttlefish, ran across these resources to. We have covered Tom Hanks several times….and his wife knows it all, or at least most of it.
Unfortunately some of the YouTube resources were dead links as “account
Previous Pizzagate submissions regarding satanic pedophile Tom Hanks…I dug this image and song out.
https://open.spotify.com/track/5EMgsRhy4oqeqTLsuT36lm?si=6v1SjroFTYuCJvSM8999Fw&nd=1
=
– https://searchvoat.co/v/pizzagate/1678698
– https://searchvoat.co/v/pizzagate/3715105
– https://searchvoat.co/v/pizzagate/3719739
– https://searchvoat.co/v/pizzagate/2665343
– https://searchvoat.co/v/pizzagate/2649565
One place mentioned in UK was “Bounce” where Hanks is known as a Ping Pong Champion (little boy over), and their galllery is now a 404, but they sure promote the Drag Queens…sheesh. Picture at top, and sure, this doesn’t look fishy….
Funny how offspring of Sigmund Freud end up in nefarious positions.
WOW! I was literally reading about this guy’s dad, Clement Freud before I saw this post!! I can fill in some blanks.
Clement Freud was the grandson of Sigmund Freud the “great” child psychologist, who came up with the Oedipus complex https://en.m.wikipedia.org/wiki/Oedipus_complex
Clement Freud died in 2009. After he died several woman came out, and said he sexual abused them then they were children. https://en.m.wikipedia.org/wiki/Clement_Freud
Clement wife Jill had an affair with a 16 year old kid when she was 47 years old! http://www.dailymail.co.uk/news/article-3641876/Dark-secrets-Freuds-Did-wife-47-seduced-boy-16-turn-blind-eye-Clement-s-depravity.html?amp&
Matthew Freud (Clement’s son) is a PR guru and was MARRIED TO RUPARD MURDOCK daughter Elizabeth!! https://en.m.wikipedia.org/wiki/Matthew_Freud
Here’s a picture of Matthew at the Bounce ping pong launch party http://www.contactmusic.net/pictures/3313222#slider-13
I haven’t looked into Clement’s other kids, so if anyone wants to do some digging be my guest.
Godwillwin4 years ago
I found this but it may not be related at all but it might be worth looking into from other angles. At the end of the article it says the abuse at this school is likely far more worse and widespread than we know http://www.telegraph.co.uk/news/worldnews/northamerica/usa/9317693/Paedophile-scandal-at-James-Murdochs-former-New-York-school.html
Mad_As_Hell4 years ago
His daughter Emma is married to film director Richard Curtis. Their 18 year old son had a fling with Kate Moss
micha_4 years ago
It has been some time, since I played table tennis, but according to the photos he doesn’t even can hold the paddle correctly. Can’t play forehand with that grip…
Clinker4 years ago
Going to SnapChat… Remember who else just went to work for Snapchat: Jennifer Stout. She is one of the infamous people called out by the FBI as the 7th floor Shadow Government that sorted through Hillary’s email, cleansing it for the FOIA requests. Business Insider Article She worked for Joe Biden in the late 90’s.
Also, remember what Snapchat is used for: Teens to send nude pics to each other. Wouldn’t the CIA love to collect those!