The
vagus nerve, a bundle of fibers that originates in the brain stem and
innervates major organs, including the gut, may be the primary route
through which pathological triggers of Parkinson’s travel from the
gastrointestinal tract to the brain. Recent epidemiological examinations
of vagotomy patients whose vagus nerves were severed show that they
have a lower risk of developing Parkinson’s. Researchers have also demonstrated
that alpha-synuclein fibers, injected into the gastrointestinal tracts
of rodents, can traverse through the vagus into the brain.
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